The CHF Alliance is a pan-Canadian, patient-driven research network dedicated to overcoming the challenges of heart failure (HF) to improve its prediction, prevention, diagnosis and management. It brings together Canada’s most innovative HF researchers and clinical experts, together with patients with lived experience, Indigenous elders and knowledge holders, government, policy makers, knowledge users, not-for-profit organizations, health care providers, academic institutions and industry partners. CHF Alliance is funded by CIHR and Heart and Stroke ($5M), with over $20M from industry, charitable foundations, and universities. The Alliance spans the patient lifecycle, from rural to urban, across geographic and socioeconomic barriers. CHF Alliance is led by Dr. Jean Rouleau (Montreal) and Mr. Marc Bains (Vancouver) a heart transplant recipient and the Vice President of HeartLife,  and co-led by Dr. Salim Yusuf (Hamilton) and Dr. Anique Ducharme (Montreal). It comprises 150 participants (including 26 early career investigators), 30 collaborators, 25 patient and family partners, 14 industry partners, and over 20 trainees. CHF Alliance is organized around four national Research Teams, two Collaborative Research Projects/Programs, seven Cross Cutting Themes, and five supporting Platforms.