CADeN is a pan-Canadian organization comprised of clinicians from across all provinces (hundreds), patient partners (N=5-10), policy makers (N=5) and academic researchers (N=20+) working together to mobilize knowledge and study medication appropriateness. CADeN researchers have led multiple trials (N=8) having randomized thousands (N>10,000) of patients. Some research endeavors are now reimbursed as a part of provincial policies for drug safety (e.g., SaferMedsNL and MedSafer LTC, a Canadian made software for deprescribing). The Network has strong, established partnerships with US, Australian, and European counterparts, with the capacity to scale up Canadian-led medication appropriateness trials internationally. CADeN Scientific Director (McDonald; co-PA on ACT; member of the ACT Operations Committee) ran the largest ever randomized controlled trial of deprescribing (N=5698 participants; 11 centers), published in JAMA Internal Medicine. The Network trains the next generation of researchers in medication safety and currently hosts several HQPs: graduate students (MSc, PhD), visiting international graduate and postgraduate research fellows, and CIHR funded Health System Impact Fellows.