The Clinical Trial Unit at the Rady Faculty of Health Sciences has experience in designing and conducting large multi-national randomized trials from project inception to completion. The Unit’s expertise in leading platform trials is a notable strength that was realized during the COVID pandemic. The diverse skills of the trial unit staff reflect the skillsets required to successfully conduct and complete traditional and novel RCTs. In addition to contracting, insurance and regulatory proficiency, the unit has been recognized as a leader in Bayesian adaptive platform trials.